Then came the pig. Yuk joined the Mayo Clinic team, which was better equipped to work with larger animals. The team wanted to avoid relying on the ability of the blood to clot naturally, as many people who have surgery have problems with their own clotting. Therefore, before any experiments, three test pigs received heparin, which thins the blood. The researchers cut three holes in each animal’s liver, 1 cm wide and 1 cm deep, then treated nine wounds with paste or Texal patch.
Tiffany Sarafian, one of the team’s veterinary surgeons, says she has never seen a glue work like this. “We just applied the paste, and we’re counting,” says Surfrian for a few seconds, remembering the procedure. “You take your hand off and you’re like, ‘Wait, there’s no blood!’ It was amazing. “
Sarafian planned that if the commercial patch of comparison did not work after three minutes, she would reverse the anticoagulant to keep the pigs alive, and then allow them to freeze and recover naturally. But it also added another step to stop the rapid bleeding: sticking to a pea-sized extract of experimental glue. “It’s kind of miraculous,” she says.
To be fair, coagulant patches like TachoSil are not designed to block heavy blood flow to tissue that causes involuntary injuries. But in medicine, it is an unnecessary necessity, says Christoph Nabzdek, a surgeon at the Mayo team. “With a growing population, you have more and more patients who have either had a bleeding disorder or are about to have a blood thinner,” he says. “The problem of bleeding, and controlling the bleeding is enough.”
He and Sarafian added that there is a cheap glue that prevents large amounts of blood. And Going to already wet surfaces would potentially be life-saving for patients, and would be especially useful in areas where there are not many surgical resources, such as in desert areas, war zones or less developed countries. ۔
“There’s nothing new in the material, but the concept is really cool and unconventional,” said Shrike Zhang, a biomedical engineer who leads the lab at Harvard Medical School. While materials such as silicone oils and adhesives are common, their Collection Makes something interesting “It’s too early, but the animal figures are strong enough,” he continues.
But, Wang, a Stanford Cardio Thoracic Surgery resident, says there are still elements that need to be improved in humans before the adhesive can be used. A glue globe that seals damaged tissue in an emergency, or sticks to nearby healthy tissue, can complicate any subsequent surgery. The question is, will you be able to work in this area? He asks
The UK team devised a solution to reverse this type of adhesive seal, and initial results in mice are promising.
They also want to know how long the seal lasts. Ideally, it should not dissolve until the tissue heals on its own, but it should not last forever. New research shows that in a separate experiment using mice, the paste dissolves significantly in 12 weeks based on microscope images. Depending on the response to the injury, it may be enough.
Another challenge is that other types of sealants are known to kill tissue over time. Wang and Yuk noted that a long-term study would be necessary. So far, their longest observation on blood organs has been about one month after the application of glue, using the Mayo Clinic Pig.
And although there may still be many years when the sealant paste replaces the reliable suture, both surgeons and mechanical engineers will welcome the ability of patients to connect to each other quickly, so that the bodies can be re-oiled well. Run like machines.
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