Immunocompromised man has 4 shots of COVID-19 vaccine but still appears to be immunocompromised

Marian Gino

A file photo shows a woman receiving a COVID-19 booster dose in Florida on October 5, 2021. AP Photo/Lynne Sladky

  • An Ohio man reported “no antibodies at all” after four shots of COVID-19, according to CNN.

  • Andrew Linder, who is immunocompromised, works to isolate and reduce contact with people.

  • The antibody test he performed has some limitations as a proxy for immunogens.


An immunocompromised man had an antibody test that came back negative even after receiving four doses of the COVID-19 vaccine, CNN reported Tuesday.

“I had absolutely no antibodies. It was shocking, frightening and alarming,” Andrew Linder, a kidney transplant recipient in Akron, Ohio, told CNN.

Because he’s not sure he’s protected from the coronavirus, Linder, 34, remains at home nearly all the time and strictly limits his contact with people other than his wife, according to CNN.

Linder takes immunosuppressants, medications commonly used after transplants to prevent the body from rejecting the new organ.

“I almost feel unsafe or if not likely to be a little less safe now than I did at the start of the pandemic, just because I might have it at this point in time,” Linder told CNN.

It was not immediately clear how Linder assessed his antibody level. The common method is by antibody testing, although this has been criticized as an incomplete tool.

The Food and Drug Administration advises against their use To check immunity.

Anthony Fauci, the White House’s chief medical advisor, He previously told Insider’s Hilary Brooke, that there are problems with them as a measure of whether the body is responding properly to the vaccine.

One reason is that protecting the body from the virus is complex, and the absence of measurable antibodies in the blood does not necessarily mean that the injection Does not provide protection.

Some people with immunodeficiency Increased risk of serious illness from COVID-19They resort to tests to give them some reassurance that the shots have worked, Scientific American reported.

Vaccines are the best protection Against hospitalization and death from COVID-19Even among immunocompromised persons.

But early data suggests that Two shots of the vaccine may provide less protection for people who are immunocompromised.

The CDC study was published last week It found that two doses of the Pfizer and Moderna vaccines reduced the risk of hospitalization by 77% among immunocompromised adults, compared to 90% among immunocompetent adults.

Last month, the Centers for Disease Control and Prevention (CDC) recommended that most adults with compromised immune systems can receive it. Up to four doses of Pfizer’s Moderna COVID-19 vaccines – Guidance is a little different for those who have it The first shot of the J&J vaccine.

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